Wagenknecht is known for pioneering the use of drones in painting and other mechanized forms of art in the early 2000s while based in New York.
Her works are often recognized for their experimental co-creative aspects, exploring the relationship between technology and the vulnerabilities of being alive. Previous exhibitions and works held in permanent collections include the Centre Pompidou, Istanbul Modern, Whitechapel Gallery, Whitney Museum of American Art, and the New Museum in New York, among others. She has collaborated with CERN, Chanel, Coinbase, and Google's Art Machine Intelligence (AMI) Group. Her work has been featured in publications such as TIME, The Wall Street Journal, Vanity Fair, Art in America, and The New York Times. Wagenknecht has held fellowships at Eyebeam Art + Technology Center in New York City, Culture Lab UK, Institute HyperWerk for Postindustrial Design in Basel (CH), and The Frank-Ratchye STUDIO for Creative Inquiry at Carnegie Mellon University.
- Wagenknecht recorded her search through hundreds of video chat rooms looking for another woman, moving on as soon as her next potential conversation partner was revealed as anyone but. Within a few seconds, each of the works reinforces the disturbing gender imbalance and fundamental weirdness of the online experience, as the artist is served up a steady stream of dudes lying in bed, dudes wearing only a towel, serving active military duty—and nothing else except the occasional empty room. Commissioned by the Museum of Moving Image, New York City